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科学研究

科技部中青年科技创新领军人才

张宁

浏览次数: 发布时间:2017-10-12
字号: + - 14

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姓    名:张宁  性    别:男        出生日期:1970年11月18日

个人简介

张宁,男,教授, 国家万人计划、国家杰出青年科学基金获得者、科技部中青年科技创新领军人才、人事部百千万人才、突出贡献专家、教育部新世纪优秀人才、天津市杰出人才、天津市特聘教授、天津市“千人计划”入选者,天津市杰出人才, 美国李氏基金会杰出成就奖获得者。现担任中国抗癌协会常务理事、副秘书长,中国抗癌协会纳米肿瘤学专业委员会主任委员,美国癌症研究协会会员,《Cancer Biology & Medicine》常务副主编。天津市政协委员。

张宁教授长期从事生物医学及细胞生物学研究,围绕肿瘤转移这一关键临床难题,从机理研究、生物标志物鉴定、药物筛选、纳米技术等多个侧面入手展开转化应用研究,取得了一系列科研成果。发现并阐述了PKCζ、PDK1、Akt2、Rictor、ELMO1、Txnl2等一系列信号分子调控细胞运动的功能和机理,初步揭示了一个调控癌细胞趋化运动的信号传导通路,这一工作为抑制肿瘤的浸润和转移提供了新的药物靶点,为肿瘤的诊断提供了新的标志物。建立了一个新的药物筛选细胞模型,筛选获得两个先导化合物,一个抗癌转移化合物,已申请专利并开展临床前研究工作。近年来开始将研究领域拓展至纳米肿瘤学领域,进行纳米技术在肿瘤诊疗中的应用研究,建立了一系列肿瘤纳米检测新方法和手段,构建了一系列纳米新材料。

基于以上研究,张宁教授近五年在Gastroenterology, Journal of Clinical Investigation、Nature Communications、ACS nano、Genome Research、Nucleic Acid Research、Biomaterials、Cancer Research等国际期刊中发表多篇文章;获得授权国际专利2项。

 

学历与科研工作经历

2010-2017    天津医科大学副校长,天津市基础医学研究中心主任。

 

2008-2017    天津市基础医学研究中心,主任,教授。主要从事癌细胞趋化运动机理研究及抗癌转移药物筛选。

 

2007-2008  天津医科大学附属肿瘤医院,天津肿瘤研究所,教授,副所长,中心实验室主任。主要从事癌细胞趋化运动机理研究及抗癌转移药物筛选。

 

2005-2007  美国奥克兰大学助理教授。主要从事生物学教学和癌扩散机理研究。

 

2003-2005   北京大学化学学院化学生物学系,副教授,副系主任。主要从事教学和趋化因子功能研究。

 

2001-2003   美国国立癌症研究所博士后研究员。师从趋化因子领域奠基人Dr. Joost J Oppenheim。研究趋化因子受体在肿瘤、免疫及神经中的功能。

 

1995-2001   美国约翰霍普金斯大学医学院 (The Johns Hopkins University School of Medicine),生化、细胞及分子生物学博士,师从Prof. Peter N. Devreotes,研究真核细胞趋化运动机理。

 

1991-1995    美国佐治亚大学,学士,硕士。师从Dr. Michael Pierce。从事癌细胞中的转糖酶和癌转移的研究。

 

1988-1991    北京大学化学系,攻读本科学位,后转学美国。

      

主要学术任职

中国抗癌协会 常务理事 副秘书长

创建中国抗癌协会纳米肿瘤学专业委员会 主任委员

天津市细胞生物学学会 副理事长

天津市生物医学工程学会 副理事长

《Cancer Biology & Medicine》 常务副主编

 

社会工作

1997-2000  先后担任约翰.霍普金斯大学医学院中国学生、学者联谊会高级顾问、主席。

1998年 作为留美学生学者代表得到朱镕基总理接见。

1999年 作为留美学生学者代表迎接江泽民总书记。组织了大华府地区中国学生学者在白宫后杰弗逊广场的游行,抗议美军轰炸南斯拉夫中国领事馆。负责申请游行许可证。

 

获奖情况

2013年 人事部百千万人才、突出贡献专家

2013年 科技部中青年科技创新领军人才

2011年 国家杰出青年科学基金获得者

2010年 天津市千人计划

2009年 天津市青年科技奖

2008年 天津市十佳杰出留学人员

2007年 教育部新世纪人才

2007年 天津市特聘教授

2004年 美国李氏基金杰出成就奖

2004年 美国国立卫生院研究优秀奖

 

应邀编写的学术专著

 

1. Oppenheim, J.J. and Zhang N.: Crosstalk between chemokine, opioid, and vanilloid receptors.  Moser, B., Letts, G., and Neote, K. (Eds). In Chemokine Biology: Basic Research and Clinical Application. Vol. I: Immunology of Chemokines. Birkhauser Publishing, Basel, Switzerland. 2005, pp 137. (ISBN号:9783764373078)

 

2. Zhang, N. and Oppenheim, J.J.: Neuropeptides that regulate immune responses. A. J. Kastin, (Ed.). In: Handbook of Biologically Active Peptides. Academic Press, Elsevier, London, UK. 2005. (ISBN号:9780123694423)

 

发表文章:

 

1. Chen R, Liu Y, Zhuang H, Yang B, Hei K, Xiao M, Hou C, Gao H, Zhang X, Jia C, Li L, Li Y, Zhang N*.  Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation. Nucleic Acids Research 2017, Sep 29 (17), 9947-59

 

2. Gao Y, Ni X, Guo H, Su Z, Ba Y, Tong Z, Guo Z, Yao X, Chen X, Yin J, Yan Z, Guo L, Liu Y, Bai F, Xie XS, Zhang N*. Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumour cells. Genome Res. 2017 May 9

 

3. Wang Y, Fu D, Su J, Chen Y, Qi C, Sun Y, Niu Y, Zhang N*, Yue D. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells. Sci Rep. 2017 Apr 20;7(1):999

 

4. Chen L, Fu H, Luo Y, Chen L, Cheng R, Zhang N*, Guo H. cPLA2α mediates TGF-β-induced epithelial-mesenchymal transition in breast cancer through PI3k/Akt signaling. Cell Death Dis. 2017 Apr 6;8(4):e2728. 

 

5. Yang B, Liu Y, Zhao J, Hei K, Zhuang H, Li Q, Wei W, Chen R, Zhang N*, Li Y. Ectopic overexpression of filamin C scaffolds MEK1/2 and ERK1/2 to promote the progression of human hepatocellular carcinoma. Cancer Lett. 2017 Mar 1;388:167-176. 

 

6. Liu Y, Wan GY, Guo H, Liu YY, Zhou P, Wang H, Wang D, Zhang S, Wang Y, and Zhang N*. A multifunctional nanoparticle system combines sonodynamic therapy and chemotherapy to treat hepatocellular carcinoma. Nano Research 2017, 10(3):834-855.

 

7. Gan W, Schneidman D, Zhang N, Ma B, Nussinov R. Probing Oligomerized Conformations of Defensin in the Membrane. Methods Mol Biol. 2017;1529:353-362 

 

8. Wan GY, Liu Y, Chen BW, Liu YY, Wang YS, Zhang N*. Recent advances of sonodynamic therapy in cancer treatment. Cancer Biol Med. 2016 Sep;13(3):325-338

 

9. Fu H, Qi L, Chen L, He Y, Zhang N*, Guo H. Expression of Ovol2 is related to epithelial characteristics and shows a favorable clinical outcome in hepatocellular carcinoma. Onco Targets Ther. 2016 Sep 29;9:5963-5973

 

10. Sun L, Burnett J, Gasparyan M, Xu F, Jiang H, Lin CC, Myers I, Korkaya H, Liu Y, Connarn J, He H, Zhang N, Wicha MS, Sun D. Novel cancer stem cell targets during epithelial to mesenchymal transition in PTEN-deficient trastuzumab-resistant breast cancer. Oncotarget. 2016 Jun 6.

 

11. Gao H, Bi Y, Chen J, Peng L, Wen K, Ji P, Ren W, Li X, Zhang N, Gao J, Chai Z, Hu Y. Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy. ACS Appl Mater Interfaces. 2016 Jun 7.

 

12. Wang F, Qiao L, Lv X, Trivett A, Yang R, Oppenheim JJ, Yang D, Zhang N*. Alarmin human α defensin HNP1 activates plasmacytoid dendritic cells by triggering NF-κB and IRF1 signaling pathways. Cytokine. 2016 Jul;83:53-60.

 

13. Han G, Gu B, Cao L, Gao X, Wang Q, Seow Y, Zhang N, Wood MJ, Yin H. Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice. Nat Commun. 2016 Mar 11;7:10981.

 

14. Ren Y, Wang R, Gao L, Li K, Zhou X, Guo H, Liu C, Han D, Tian J, Ye Q, Hu YT, Sun D, Yuan X, Zhang N*. Sequential co-delivery of miR-21 inhibitor followed by burst release doxorubicin using NIR-responsive hollow gold nanoparticle to enhance anticancer efficacy. J Control Release. 2016 Apr 28;228:74-86.

 

15. Wang F, Qiao L, Chen L, Zhang C, Wang Y, Wang Y, Liu Y, Zhang N*. The immunomodulatory activities of pullulan and its derivatives in human pDC-like CAL-1 cell line. Int J Biol Macromol. 2016 May;86:764-71.

 

16. Chen R, Xiao M, Gao H, Chen Y, Li Y, Liu Y, Zhang N*. Identification of a novel mitochondrial interacting protein of C1QBP using subcellular fractionation coupled with CoIP-MS. Anal Bioanal Chem. 2016 Jan 11. [Epub ahead of print] (通讯作者)

 

17. Xue R, Li R, Guo H, Guo L, Su Z, Ni X, Qi L, Zhang T, Li Q, Zhang Z, Xie XS, Bai F, Zhang N*. Variable Extent of Intra-tumor Heterogeneity Revealed by Genomic Sequencing of Multiple Lesions in Patients with Hepatocellular Carcinoma. Gastroenterology. 2016 Jan 2. pii: S0016-5085(15)01861-2. doi: 10.1053/j.gastro.2015.12.033.  (共同通讯作者)

 

18. Tang B, Wang J, Hutchison JA, Ma L, Zhang N, Guo H, Hu Z, Li M, Zhao Y. Ultrasensitive, Multiplex Raman Frequency Shift Immunoassay of Liver Cancer Biomarkers in Physiological Media. ACS Nano. 2016 Jan 11. [Epub ahead of print] 

 

19. Zuo D, Chen L, Liu X, Wang X, Xi Q, Luo Y, Zhang N*, Guo H. Combination of miR-125b and miR-27a enhances sensitivity and specificity of AFP-based diagnosis of hepatocellular carcinoma. Tumour Biol. 2015 Dec 4. [Epub ahead of print]  (共同通讯作者)

 

20. Burnett JP, Korkaya H, Ouzounova MD, Jiang H, Conley SJ, Newman BW, Sun L, Connarn JN, Chen CS, Zhang N, Wicha MS, Sun D.Trastuzumab resistance induces EMT to transform HER2(+) PTEN(-) to a triple negative breast cancer that requires unique treatment options. Sci Rep. 2015 Nov 2;5:15821. doi: 10.1038/srep15821. 

 

21. Sun B, Chen L, Fu H, Guo L, Guo H, Zhang N*. Upregulation of RICTOR gene transcription by the proinflammatory cytokines through NF-κB pathway contributes to the metastasis of renal cell carcinoma. Tumour Biol. 2015 Oct 25. [Epub ahead of print] (通讯作者)

 

22. Yong Wang, Dan Yue, Mingming Xiao, Can Qi, Yajing Chen, Duxin Sun, Ning Zhang*, Ruibing Chen*. C1QBP Negatively Regulates the Activation of Oncoprotein YBX1 in the Renal Cell Carcinoma As Revealed by Interactomics Analysis. Journal of Proteome Research. 2014 Dec 26. [Epub ahead of print]  (共同通讯作者)  

23. Yuanyuan Liu, Yan Wang, Cong Zhang, Ping Zhou, Yang Liu, Tong An, Duxin Sun, Ning Zhang*, Yinsong Wang*. Core-Shell Nanoparticles Based on Pullulan and Poly(β-amino) Ester for Hepatoma-Targeted Codelivery of Gene and Chemotherapy Agent. ACS Applied Materials & Interfaces. 2014 Nov 12;6(21):18712-20. (共同通讯作者)  

 

24. Hua Guo, Yuanyuan Liu, Yan Wang, Jing Wu, Xiaoying Yang, Rongshan Li,Yinsong Wang*, Ning Zhang*. pH-sensitive pullulan-based nanoparticle carrier for adriamycin toovercome drug-resistance of cancer cells. Carbohydrate Polymers. 2014 Oct 13; 111: 908–917.(共同通讯作者)  

25. Yu Ren, Ruirui Wang, Yang Liu, Hua Guo, Xuan Zhou, Xubo Yuan, Chaoyong Liu, Jianguo Tian, Haifang Yin, Yinsong Wang*, Ning Zhang*. A hematoporphyrin-based delivery system for drug resistance reversal and tumor ablation. Biomaterials. 2014 Mar;35(8):2462-70.   (共同通讯作者)   

26. Yinsong Wang*, Yang Liu, Yuanyuan Liu, Yan Wang, Jing Wu, Rongshan Li, Jinrong Yang, Ning Zhang*. pH-sensitive pullulan-based nanoparticles for intracellular drug delivery. Polymer Chemistry. 2014;5(2):423-32.  (共同通讯作者)  

27. Yuanyuan Liu, Yi Luo, Jing Wu, Yinsong Wang*, Xiaoying Yang, Rui Yang, Baiqi Wang, Jingrong Yang, Ning Zhang*. Graphene oxide can induce in vitro and in vivo mutagenesis. Scientific Reports. 2013 Dec 11;3:3469.   (共同通讯作者)   

 

28. Xiaofang Zhang, Fei Zhang, Lin Guo, Yanping Wang, Peng Zhang, Ruirui Wang, Ning Zhang*, Ruibing Chen*. Interactome analysis reveals that C1QBP is associated with cancer cell chemotaxis and metastasis. Molecular & Cellular Proteomics. 2013 Nov;12(11):3199-209 (共同通讯作者)  

29. Xiujun Gao, Ping Zhou, Rui Yang, De Yang, Ning Zhang*. Protein-loaded comb-shape copolymer-based pH-responsive nanoparticles to improve the stability of proteins. Journal of Materials Chemistry B. 2013 Sep; 1(38):4992-5002    (通讯作者)  

30. Linyi Dong, Binfeng Cheng, Yi Luo, Ning Zhang, Hongquan Duan, Min Jiang, Yiming Wang, Gang Bai, Guoan Luo*. Identification of Nuclear Factor-κB Inhibitors and β2 Adrenergic Receptor Agonists in Chinese Medicinal Preparation Fuzilizhong Pills Using UPLC with Quadrupole Time-of-flight MS. Phytochemical Analysis. 2014 Mar;25(2):113-21     (第四作者)   

31. Linyi Dong, Yi Luo, Binfeng Cheng, Yaoshu Zhang, Ning Zhang, Yuanyuan Hou, Min Jiang*,  Guoan Luo, Gang Bai*. Bioactivity-integrated ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry for the identification of nuclear factor-κB inhibitors and β2 adrenergic receptor agonists in Chinese medicinal preparation Chuanbeipipa dropping pills. Biomedical Chromatography. 2013 Aug;27(8):960-7   (第五作者)  

32. Baoxing Chang, Xianjun Yang, Fang Wang, Yinsong Wang, Rui Yang, Ning Zhang*, Baiqi Wang*. Water soluble fluorescence quantum dot probe labeling liver cancer cells. Journal of Materials Science: Materials in Medicine. 2013 Nov;24(11):2505-8 (共同通讯作者)  

33. Jiao Zhang, Xin Wang, Wenjing Cui, Wenwen Wang, Huamei Zhang, Lu Liu, Zicheng Zhang, Zheng Li, Guoguang Ying, Ning Zhang, Binghui Li*. Visualization of caspase-3-like activity in cells using a genetically encoded fluorescent biosensor activated by protein cleavage. Nature Communications. 2013 Jul 16;4:2157.  (第十作者) 

34. Yinsong Wang*, Hongli Chen, Yuanyuan Liu, Jing Wu, Ping Zhou, Yan Wang, Rongshan Li, Xiaoying Yang, Ning Zhang*. pH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma. Biomaterials. 2013 Sep;34(29):7181-90.  (共同通讯作者)  

35. Hongyan Li, Lei Yang, Hui Fu, Jianshe Yan, Ying Wang, Hua Guo, Xishan Hao, Tian Jin, and Ning Zhang*. Association between G alpha i2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis. Nature Communications. 2013 Apr 16;4:1706. (通讯作者)   

 

36. Ruibing Chen, Yanping Wang, Yan Liu, Qing Zhang, Xiaofang Zhang, Fei Zhang, Chia-Hui Paul Shieh, De Yang, Ning Zhang*. Quantitative Study of the Interactome of PKCζ Involved in the EGF-induced Tumor Cell Chemotaxis. Journal of Proteome Research. 2013 Mar 1;12(3):1478-86 (共同通讯作者)   

 

37. Yueguo Li, Jing Wu, Weiming Zhang, Ning Zhang*, Hua Guo*. Identification of serum CCL15 in hepatocellular carcinoma. British journal of cancer. 2013 Jan 15;108(1):99-106 (共同通讯作者)  

 

38. Jing Wu, Yinsong Wang*, Xiaoying Yang, Yuanyuan Liu, Jinrong Yang, Rui Yang, Ning Zhang*. Graphene oxide used as a carrier for adriamycin can reverse drug resistance in breast cancer cells. Nanotechnology. 2012 Sep 7;23(35):355101 (共同通讯作者)  

 

39. Huiyuan Zhai, Chuan Zhao, Ning Zhang, Meina Jin, Shengan Tang, Nan Qin, Dexin Kong, Hongquan Duan*. Alkaloids from Pachysandra terminalis Inhibit Breast Cancer Invasion and Have Potential for Development As Antimetastasis Therapeutic Agents. Journal of Natural Products.  2012 Jul 27;75(7):1305-11.  (第三作者) 

 

40. Xiaolin Zhu, Peng Chen, Hua Guo, Wenjing Hou, Yu Shi, Ti Zhang, Qiang Li*, Ning Zhang. Relationships among Differentiation Degree, Contrast-Enhanced Ultrasound and the Expression of Ephb4/Ephrinb2 in Primary Hepatocarcinoma. Hepato-Gastroenterology. 2012 Jun;59(116):1164-7. (第八作者)

 

41. Hongyan Li, Jing Wu, Guoguang Ying, Liwei Chen, Luhua Lai, Zhe Liu, Ning Zhang*, Hua Guo*. J-4: a novel and typical preclinical anticancer drug targeting protein kinase C ζ. Anticancer Drugs. 2012 Aug;23(7):691-7.(共同通讯作者)    

 

42. Yan Liu, Fei Zhang*, Xiaofang Zhang, Lisha Qi, Lei Yang, Hua Guo, Ning Zhang*. Expression of Nucleophosmin/NPM1 correlates with migration and invasiveness of colon cancer cells. Journal of Biomedical Science. 2012 May 25;19(1):53.(共同通讯作者)   

 

43. Li Fu*, Xiaolei Liu, Yanmei Niu, Hairui Yuan, Ning Zhang, Ehud Lavi. Effects of high-fat diet and regular aerobic exercise on global gene expression in skeletal muscle of C57BL/6 mice. Metabolism-Clinical And Experimental 2012 Feb;61(2):146-52.(第五作者)   

 

44. Yinsong Wang*, Xiaoying Yang, Jinrong Yang, Yumei Wang, Rou Chen, Jing Wu, Yuanyuan Liu, Ning Zhang*. Self-assembled nanoparticles of methotrexate conjugated O-carboxymethyl chitosan: Preparation, characterization and drug release behavior in vitro. Carbohydrate Polymers 2011Oct; 86(4):1665-70(共同通讯作者)   

 

45. Peng Chen, Xiaofang Zhang, Hua Guo, Ning Ma, Menghui Li, Zhe Liu, Ning Zhang*, Xishan Hao*. Effect of 4-methyl-3-nitrobenzoic acid on non‑small cell lung cancer cell migration. Molecular Medicine Reports 2011 Sep-Oct;4(5):947-53(共同通讯作者)    

 

46. Gang Tian, Xueqian Wang, Fei Zhang, Hua Geng, Wei Hou, Liwei Chen, Hua Guo*, and Ning Zhang*. Downregulation of cPLA(2)γ expression inhibits EGF-induced chemotaxis of human breast cancer cells through Akt pathway. Biochemical and Biophysical Research Communications 2011 Jun 10;409(3):506-12.(共同通讯作者)  

 

47. Hua Guo, Menghui Li, Peng Chen, David J. Blake, Xiaoni Kong, Xishan Hao, Ruifang Niu*, Ning Zhang*. 4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice. Cancer Letters 2011 Jun 1;305(1):69-75. (共同通讯作者)  

 

48. Song C, Rahim RT, Davey PC, Bednar F, Bardi G, Zhang L, Zhang N, Oppenheim JJ, Rogers TJ*. PKC{zeta} mediates {micro}-opioid receptor-induced cross-desensitization of CCR5. Journal of Biological Chemistry. 2011 Jun 10;286(23):20354-65.(第七作者) 

 

49. Bingbing Wang, De Yang, Baoyun Sun, Xiyin Wei, Hua Guo, Xiaoli Liu,Guoguang Ying, Ruifang Niu, Ning Zhang∗, and Yongjie Ma*. An anti-tumor nanoparticle, [Gd@C82(OH)22]n, induces macrophage activation. Journal of Nanoscience and Nanotechnology. 2011 Mar;11(3):2321-9 (共同通讯作者)

 

50. Ying Qu, Jinhua Wang, Partha S. Ray, Hua Guo, Jian Huang, Miyung Shin-Sim, Bolanle A. Bukoye, Bingya Liu, Adrian V. Lee, Xin Lin, Peng Huang, John W. Martens, Armando E. Giuliano, Ning Zhang*, Ning-Hui Cheng*, Xiaojiang Cui*. Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling. Journal of Clinical Investigation. 2011 Jan 4;121(1):212-25 (共同通讯作者)  

 

51. Chertov O, Zhang N, Chen X, Oppenheim JJ, Lubkowski J, McGrath C, Sowder RC 2nd, Crise BJ, Malyguine A, Kutzler MA, Steele AD, Henderson EE, Rogers TJ.  Novel Peptides Based on HIV-1 gp120 Sequence with Homology to Chemokines Inhibit HIV Infection in Cell Culture. PLoS One. 2011 Jan 11;6(1):e14474.  (第二作者)

 

52. Fei Zhang, Xiaofang Zhang, Menghui Li, Peng Chen, Bin Zhang, Hua Guo, Wenfeng Cao, Xiying Wei, Xuchen Cao, Xishan Hao, Ning Zhang*. mTOR Complex Component Rictor Interacts with PKC{zeta} and Regulates Cancer Cell Metastasis. Cancer Research. 2010 Nov 15; 70(22):9360-70. (通讯作者)

 

53. Jing Wang, Feng Gui, Ting Ding, Xiaoli Liu, Gengmei Xing, Yuliang Zhao, Ning Zhang*, Yongjie Ma*. [Gd@C-82(OH)(22)](n) nanoparticles inhibit the migration and adhesion of glioblastoma cells. Oncology Letters. 2010 Jul-Aug; 1(4):771-5 (共同通讯作者)

 

54. Jing Wu, Baogang Zhang, Min Wu, Hongyan Li, Ruifang Niu*, Guoguang Ying*, Ning Zhang. Screening of a PKC zeta-specific kinase inhibitor PKCzI257.3 which inhibits EGF-induced breast cancer cell chemotaxis. Investigational New Drugs. 2010 Jun;28(3):268-75.(第七作者)

 

55. Meng H, Xing G, Sun B, Zhao F, Lei H, Li W, Song Y, Chen Z, Yuan H, Wang X, Long J, Chen C, Liang X, Zhang N, Chai Z, Zhao Y. Potent angiogenesis inhibition by the particulate form of fullerene derivatives. ACS Nano. 2010 May 25;4(5):2773-83. (第十四作者)

 

56. De Yang, Yuliang Zhao, Hua Guo, Yana Li, Poonam Tewary, Gengmei Xing, Wei Hou, Joost J. Oppenheim, and Ning Zhang*. [Gd@C(82)(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses. ACS Nano. 2010 Feb 23;4(2):1178-86.(通讯作者)

 

57. Fei Zhang, Lin Zhang, Bin Zhang, Xiyin Wei, Yi Yang, Robert Zhong Qi, Guoguang Ying, Ning Zhang* , Ruifang Niu*.  Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cells. Journal of Proteome Research. 2009 Nov;8(11):5041-7.(共同通讯作者)

 

58. Wang J, Sun RH, Zhang N, Nie H, Liu JH, Wang JN, Wang H, Liu Y*. Multi-walled carbon nanotubes do not impair immune functions of dendritic cells. Carbon. 2009 Jun; 47(7):1752-60.  (第三作者)  

 

59. Baogang Zhang, Yongjie Ma,Hua Guo, Baocun Sun, Ruifang Niu, Guoguang Ying, and Ning Zhang*. Akt2 Is Required for Macrophage Chemotaxis. European Journal of Immunology 2009 Mar;39(3):894-901 (通讯作者)

 

60. Ying Liu, Jingna Wang, Min Wu, Wuzhou Wan, Ronghua Sun, De Yang, Xiangjun Sun, Dalong Ma, Guoguang Ying*, Ning Zhang*. Down-regulation of 3-phosphoinositide -dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. Molecular Cancer Research 2009 Jun;7(6):944-54..(共同通讯作者)

 

61. Hua Guo, Yongjie Ma, Baogang Zhang, Baocun Sun, Ruifang Niu, Guoguang Ying, and Ning Zhang*. Pivotal Advance: PKC zeta is required for migration of macrophages. Journal of Leukocyte Biology 2009 Jun;85(6):911-8.(通讯作者)

 

62. Hua Guo, Feng Gu, Wenliang Li, Baogang Zhang, Ruifang Niu, Li Fu, Ning Zhang*, Yongjie Ma*. Reduction of Protein kinase C zeta inhibits migration and invasion of human glioblastoma cells. Journal of Neurochemistry 2009 Apr;109(1):203-13. (共同通讯作者)

 

63. Baogang Zhang, Feng Gu, Chunhua She, Hua Guo, Wenliang Li, Ruifang Niu, Li Fu, Ning Zhang*, Yongjie Ma*. Reduction of Akt2 inhibits migration and invasion of glioma cells. International Journal of Cancer. 2009 Feb; 125(3):585-595.(共同通讯作者)

 

64. Ying Liu, BingWang, JingnaWang, WuzhouWan, Ronghua Sun, Yuliang Zhao, Ning Zhang*. Down-regulation of PKC zeta expression inhibits chemotaxis signal transduction in human lung cancer cells. Lung Cancer 2009 Feb;63(2):210-8(通讯作者)

 

65. Jingna Wang, Wuzhou Wan, Ronghua Sun, Ying Liu, Xiangjun Sun, Dalong Ma, Ning Zhang*. Reduction of Akt2 expression inhibits chemotaxis signal transduction in human breast cancer cells. Cellular Signalling 2008 Jun;20(6):1025-34..(通讯作者)  

 

66. De Yang, Qian Chen, Shao Bo Su, Ping Zhang, Kahori Kurosaka, Rachel R. Caspi, Suzanne M. Michalek, Helene F. Rosenberg, Ning Zhang, Joost J. Oppenheim. Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2- MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. Journal of Experimental Medicine. 2008;205(1):79-90

 

67. Yu M, Yang Y, Shi Y, Wang D, Wei X, Zhang N, Niu R*. Expression level of beta protein 1 mRNA in Chinese breast cancer patients: a potential molecular marker for poor prognosis. Cancer Science. 2008 Jan;99(1):173-8. (第六作者)  

 

68. Wuzhou Wan, Haixia Zou, Ronghua Sun, Ying Liu, Jingna Wang, Dalong Ma, Ning Zhang*. Investigate the role of PTEN in chemotaxis of human breast cancer cells. Cellular Signalling 2007 Nov;19(11):2227-36. (通讯作者)

 

69. Yu M, Zhou Y, Shi Y, Ning L, Yang Y, Wei X, Zhang N, Hao X, Niu R*. Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life. 2007 Jul;59(7):450-7.  

 

70. Ying Liu, Ronghua Sun, Wuzhou Wan, Jingna Wang, Joost J Oppenheim, Lin Chen, Ning Zhang*. The involvement of lipid rafts in epidermal growth factor-induced chemotaxis of breast cancer cells. Molecular Membrane Biology 2007 Mar-Apr;24(2):91-101.(通讯作者) 

 

71. Caijie Zhao, Mi Cai, Yao Zhang, Ying Liu, Ronghua Sun, and Ning Zhang*. Development of a micro scopy-based assay for protein kinase C zeta activation in human breast cancer cells. Analytical Biochemistry 2007 Mar 1;362(1):8-15.(通讯作者) 

 

72. Ning Zhang, De Yang, Ronghua Sun, Qian Chen, Dessislava I Dimitrova, Thomas J Rogers, Michail Sitkovsky, and Joost J Oppenheim. Adenosine A2a receptors induce heterologous desensitization of chemokine receptors. Blood 2006 Jul 1;108(1):38-44. (第一作者)

 

73. Ronghua Sun, Ping Gao, Lin Chen, Dalong Ma, Jiming Wang, Joost J. Oppenheim, Ning Zhang*. Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells. Cancer Research. 2005 Feb 15; 65(4):1433-41. (通讯作者)   

 

74. Ning Zhang, Inan Sateed, Alan Cowan, Ali Guler, Ronghua Sun, Jiming Wang, Thomas Rogers, Michael Caterina, and Joost Oppenheim. A Pro-inflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel, TRPV1.  Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4536-41. (第一作者)   

 

75. Ning Zhang and Joost J. Oppenheim. Crosstalk between chemokines and neuronal receptors bridges immune and nervous systems. Journal of Leukocyte Biology. 2005 Dec;78(6):1210-4.(第一作者) 

 

76. Jiao X, Zhang N, Xu X, Oppenheim JJ, Jin T. Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Molecular and Cellular Biology. 2005 Jul;25(13):5752-62.(第二作者) 

 

77. Gao P, Wange RL, Zhang N, Oppenheim JJ, Howard OM. Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.  Blood. 2005 Jun 30; 108 (1):38-44. (第三作者)   

 

78. Wei F, Chen C, Zhai L, Zhang N, Zhao XS.  Recognition of single nucleotide polyrnorphisms using scanning potential hairpin denaturation. Journal of the American Chemical Society. 2005 Apr 20;127(15):5306-7.  (第四作者) 

 

79. Zhang N, Rogers TJ, Caterina M, Oppenheim JJ.  Proinflammatory chemokines, such as C-C chemokine ligand 3, desensitize mu-opioid receptors on dorsal root ganglia neurons. Journal of Immunology. 2004 Jul 1;173(1):594-9. (第一作者) 

 

80. Ying G, Iribarren P, Zhou Y, Gong W, Zhang N, Yu ZX, Le Y, Cui Y, Wang JM. Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. Journal of Immunology. 2004 Jun 1;172(11):7078-85.(第五作者)  

 

81. Sun R, Iribarren P, Zhang N, Zhou Y, Gong W, Cho EH, Lockett S, Chertov O, Bednar F, Rogers TJ, Oppenheim JJ, Wang JM. Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor. Journal of Immunology. 2004 Jul 1;173(1):428-36.(第三作者)  

 

82. Zhang N, Hodge D, Rogers T, and Oppenheim JJ. Ca++-independent PKCs mediate heterologous desensitization of leukocyte chemokine receptors by opioid receptors. Journal of Biological Chemistry  2003 Apr 11;278(15):12729-36.(第一作者) 

 

83. Szabo I, Wetzel M, Zhang N, Steele A, Kaminsky DE, Chen C, Liu-Chen LY, Bednar F, Henderson, EE, Howard OMZ, Oppenheim JJ, and Rogers TJ. Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization. Journal of Leukocyte Biology. 2003 Dec;74(6):1074-82.(第三作者) 

 

84. Chen X, Yang L, Zhang N, Turpin JA, Osterling C, Oppenheim JJ, and Zack Howard OM.  Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1.  Antimicrobial Agents and Chemotherapy 2003 Sep;47(9):2810-6.   (第三作者) 

 

85. Zhang N, Long Y, Chang S, Devreotes PN. Ege A, a novel C2 domain containing protein, is essential for GPCR-mediated gene expression. Developmental Biology 2002 Aug 1; 248(1):1-12.  (第一作者)  

 

86. Zhang N, Long Y, Devreotes PN.  G gamma in Dictyostelium: Its role in localization of G beta gamma to the membrane is required for chemotaxis in shallow gradients.  Molecular Biology of the Cell  2001 Oct; 12(10): 3204-13. (第一作者)  

 

87. Jin T, Zhang N, Long Y, Parent CA, Devreotes PN.  Localization of the G protein beta gamma complex in living cells during chemotaxis. Science 2000 Feb 11;287(5455):1034-6. (第二作者)   IF=31.477

 

88. Xiao Z, Zhang N, Murphy DB, Devreotes PN*. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. Journal of Cell Biology. 1997 Oct 20;1399(2):365-74.  (第二作者) 

 

89. Ning Zhang, Kou-Cheng Peng, Lin Chen, David Puett and Michael Pierce*. Circular Dichroic Spectroscopy of N-Acetylglucosaminyltransferase V and Its Substrate Interactions. Journal of Biological Chemistry. 1997 Feb 14;272(7):4225-9. (第一作者)  

 

90. Lin Chen, Ning Zhang, Beverly Adler, Jeffery Browne, Nevis Freigen, Michael Pierce*. Preparation of antisera to recombinant, soluble N-acetylglucosaminyltransferase V and its visualization in situ. Glycoconjugate Journal. 1995 Dec;12(6):813-23. (第二作者) 


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